As 2025 wraps up and labs wind down, scientists across the biologics value chain – from early discovery to bioprocessing and manufacturing – share similar holiday wishes: better candidates likely to succeed in experiments, automated workflows with fewer manual steps, and optimized processes for high-quality yields. With BIOVIA, these wishes come true with the right capabilities, exactly when and where they need them.
🎁 Wish #1: Faster, Smarter Biologics Discovery
With the advances in AI and drug discovery, biologists are now navigating an increasingly complex landscape. AI-driven algorithms such as AlphaFold/OpenFold, RFdiffusion, and ProteinMPNN have opened up new possibilities for rational design – from predicting 3D structures directly from amino acid sequences to designing an entirely new protein from scratch. Yet, integrating these tools efficiently into multi-stage workflows remains challenging. Combining AI-generated predictions with physics-based modeling is also critical to refine structures or evaluate binding and stability. However, all these often mean juggling multiple software tools or command-line executables, and doing a lot of manual work, which can be slow and frustrating.
What BIOVIA delivers:
- Easy access to modern AI tools out-of-the-box
BIOVIA Discovery Studio Simulation on the 3DEXPERIENCE® platform provides easy access to novel AI algorithms – OpenFold/AlphaFold2, RFdiffusion, and ProteinMPNN – with built-in, ready-to-run protocols that bring Nobel Prize–winning science directly into drug discovery workflows.
- Combining the power of AI with molecular modeling
Users can combine the power of AI with validated physics-based molecular modeling to optimize lead candidates. For instance, they can refine their AI-generated structures with molecular dynamics simulations and follow downstream workflows, such as virtual screening via protein-protein docking, or studying and optimizing formulation properties.
- Integrated AI-powered discovery workflows for every biologist
Discovery Studio Simulation offers an automated de novo protein design workflow that accelerates and simplifies the discovery of novel protein binders for a given target. This intelligent, guided process democratizes cutting-edge AI, enabling any biologist to design high-quality candidates with AI, without specialized training.
- OpenFold3 Co-folding (Coming Soon)
Discovery Studio Simulation will offer OpenFold3 in early 2026 and expand AI capabilities for structure prediction of biomolecular complexes, starting with protein-ligand co-folding, allowing for prioritization of lead candidates early on.
With Discovery Studio Simulation, biologists can rapidly explore novel designs, evaluate candidates with confidence, and accelerate the path from idea to lab — without needing holiday magic!
🎁 Wish #2: Modern, Compliant, High-throughput Bioprocessing
Bioprocessing is undergoing a major transformation. As bioprocess labs push toward intensified, automated, and data-rich development, they need to move beyond legacy solutions. Spreadsheets, disconnected ELNs, isolated instruments, and custom scripts can no longer support the speed and complexity of modern biologics development. To thrive in a Bioprocessing 4.0 era, bioprocess teams need modern, cloud-native, automated solutions that eliminate manual tasks, enable structured, AI-ready data capture, improve operational efficiency, and support seamless scale-up — all while maintaining GxP compliance.
What BIOVIA delivers:
• A modern, cloud-native environment built for speed, scale, and Bioprocessing 4.0
BIOVIA ONE Lab provides a flexible, secure digital ecosystem designed for today’s high-throughput, data-intensive process development. Teams can run more studies, collaborate seamlessly, and scale workflows as their demands change.
• High-throughput experiment design and execution
Automated planning tools, reusable workflow templates, and integrated sample/recipe management let teams run many more experiments in parallel with far fewer manual steps, accelerating both upstream and downstream development.
• Automation that removes manual work and reduces risk
With ONE Lab’s automated instrument integration and procedure execution capabilities, teams can remove manual steps and minimize errors, and have more time to focus on science.
• Structured, searchable, AI-ready data from day one
Scientists can capture data in a standardized, structured format that can be easily compared, analyzed, and fed into AI/ML models. No more piecing together spreadsheets, manual documents, or PDFs.
• Unified materials management
Teams can register and manage complex biologic entities with a common data model, unified across all labs, making sure that IP is protected and context is preserved.
• Built-in GxP compliance across the development lifecycle
ONE Lab provides audit trails, e-signatures, controlled workflows, and secure, validated data handling. Teams maintain full compliance from early DoE through development.
• Tech transfer made smooth and predictable
Because process definitions, parameters, and historical data are captured in an industry-standard format (S88), development teams can hand off processes to manufacturing far more easily. This reduces friction, prevents ambiguity, and accelerates scale-up into GMP operations.
ONE Lab is the modern, cloud-native solution that the bioprocess teams have on their holiday wish list — where experiments scale faster, data flows seamlessly, automation reduces manual work, and decisions are made with real-time insight, with GxP compliance at each stage.
🎁 Wish #3: Efficient, Compliant, Data-driven Smart Manufacturing
Scaling biologics manufacturing is complex. Manual tasks, fragmented systems, and disconnected data make it difficult to track production, ensure quality, and respond quickly to problems. Maintaining GxP compliance across multiple sites adds another layer of difficulty.
What BIOVIA delivers:
• Single source of truth for all data
BIOVIA Discoverant brings together data from equipment, MES, LIMS, QC labs, and batch records into one central location. Teams can monitor operations in real-time, trend key parameters, and quickly spot anomalies. No more hunting through spreadsheets or disparate systems.
Users can also sync a particular hierarchy to the 3DEXPERIENCE platform, automatically pulling in all data from every batch and every parameter linked to that hierarchy in real-time, ensuring manufacturing data is centralized, always current, and accessible.
• Faster root-cause analysis and proactive interventions
With real-time analytics and statistical modeling, teams can discover process deviations in minutes instead of days and act before the quality or yield is impacted.
• Optimized, predictable operations
Continuous monitoring of critical process parameters and quality attributes helps maximize yields, reduce waste, and ensure batch-to-batch consistency. Manufacturing becomes more efficient, reliable, and scalable.
• Built-in GxP compliance and audit readiness
Discoverant ensures data integrity with secure, traceable, validated workflows, supporting 21 CFR Part 11 compliance principles. Every trend, comparison, and decision is fully documented for regulatory inspections.
• Smoother hand-off from development to production
Because process definitions, parameters, and historical data are standardized and structured, manufacturing teams can adopt new processes with confidence, reducing friction, and accelerating scale-up, therefore time-to-market.
With Discoverant, manufacturing moves from reactive, manual operations to proactive, insight-driven, and fully compliant production, helping biopharma teams deliver high-quality biologics at scale, on time, and with confidence.
⭐ The Holiday Wrap-up: From Design to Manufacturing, BIOVIA Delivers
From discovery through bioprocessing and into manufacturing, BIOVIA ties together discovery, development, and manufacturing with a perfect bow to help R&D teams deliver high-quality biologics faster. Make this holiday season magical for your biologists – schedule a call with an expert.
Dr. Ceren Tuzmen Walker is a Senior Manager of Brand Marketing at BIOVIA. She has degrees in Molecular Biology, Computational Biology and Bioengineering, and a strong background in science communication and storytelling. Since she joined BIOVIA, Ceren has been leading messaging and brand storytelling for drug discovery and data science solutions. She is passionate about empowering scientists with the right tools for accelerating innovation.